Health resilience, resilience to sickness, is not just relevant during cold and flu season any more. Those who have to travel a lot, wear masks. Those who have to be in tight places with lots of people take precautions. Hand sanitizer is kept nearby. But there is something else that people should be doing to boost immunity besides those things. Fighting sickness or fighting any chance of getting sick requires introducing the raw compounds of the cannabis plant into your system and the gentle and easy way is through the Sisters’ CBD Plus line of products.
CBD Plus means that the raw compounds and the cooked compounds of the cannabis plant are combined in one, one teaspoon or one gelcap. Each ½ tsp serving (or one gelcap serving) contains approximately 13 mg of CBGa, 11 mg of CBDa, 7 mg of CBD, and 1 mg of CBG.
The little ‘a’ after the compound tells you that it’s a raw compound (acidic). This formula was added to the Sisters’ line of products when scientists proved, during the pandemic, that the raw compounds of the cannabis plant are effective in fighting infection and disease.
A liquid coconut oil base is used for extraction and all the products are vegan, all natural, and non-psychotropic.
What Are Raw Compounds?
CBGa (Cannabigerolic acid) and CBDa (Cannabidiolic acid) are the acidic precursors to CBG and CBD, respectively. In other words, it’s the form of the natural plant, which converts to another form when it is cooked. Unlike their “decarboxylated” (heated) forms, these compounds remain in their raw state and are known to interact differently with the body.
Efficacy of CBGa and CBDa in Fighting Infections
A study published in the Journal of Natural Products in 2022 suggested that CBGa and CBDa can block the entry of the SARS-CoV-2 virus into human cells by binding to the spike protein, which prevents it from infecting cells. This study highlights that raw cannabinoids, especially CBGa and CBDa, help in reducing viral infection, including COVID-19 .
These raw compounds are believed to have anti-inflammatory and antiviral properties that help in preventing infection by interacting with the body’s immune system. Raw cannabinoids, such as CBGa and CBDa, work by influencing the endocannabinoid system (ECS), which plays a significant role in immune response regulation.
Other Benefits of Raw Cannabinoids
CBGa and CBDa may offer heightened anti-inflammatory effects compared to their decarboxylated forms. These compounds have also been linked to benefits in digestive health (such as reducing inflammation in conditions like colitis) and neuroprotection, helping to protect against neurological diseases like Alzheimer’s.
The Entourage Effect: Combining Cooked and Raw Compounds
The entourage effect refers to the synergistic relationship between different cannabinoids, terpenes, and other compounds in the cannabis plant. It suggests that the combined effect of these compounds is greater than their individual effects.
The combination of raw and decarboxylated compounds found in the CBD Plus products —CBGa, CBDa, CBD, and CBG—provides a more robust and effective formula for health and healing. CBGa and CBDa (raw) have specific antiviral and anti-inflammatory effects, while CBD and CBG (decarboxylated) are known for their anti-anxiety, anti-pain, and overall wellness benefits. Together, they create a synergistic blend that offers both preventative (CBGa/CBDa’s infection-fighting properties) and restorative (CBD/CBG’s healing and relief from pain and anxiety) benefits.
Real-World Applications of the Entourage Effect
Studies show that combining multiple cannabinoids can enhance therapeutic effects. For example, research on multiple sclerosis patients found that a combination of THC and CBD improved spasticity better than THC alone. The CBD Plus line taps into this principle by mixing raw and decarboxylated compounds, offering more comprehensive health support.
Why Lab-Tested, State-Licensed Products Matter
Reason #1: CBD (Cannabidiol)
CBD treats pain, anxiety, inflammation, seizures, and sleep disorders. It is commonly used for chronic pain management, reducing inflammation, and managing arthritis symptoms. Known for its calming properties, CBD interacts with serotonin receptors, which can help reduce symptoms of anxiety and depression.
CBD is approved as a treatment for certain types of epilepsy (e.g., Epidiolex for Lennox-Gastaut syndrome). Some users report curative results, especially for conditions related to inflammation or stress.
Reason #2: CBDa (Cannabidiolic Acid)
CBDa treats nausea, diabetes, heart health, and inflammation. CBDa has shown promise in reducing nausea, especially in chemotherapy patients. Early research indicates that CBDa may help reduce obesity-related complications and maintain proper insulin sensitivity. CBDa is a contender medicine for helping reduce inflammation in blood vessels, improving overall cardiovascular health.
CBDa, in its raw form, is thought to have stronger anti-inflammatory properties than heated (decarboxylated) CBD.
Reason #3: CBGa (Cannabigerolic Acid)
CBGa treats infection, inflammation, cancer prevention (early research) and metabolic disorders. Combined with CBDa, CBGa has been shown to help fight viral infections, including SARS-CoV-2, by blocking viral entry into human cells. Research suggests CBGa could help regulate metabolic disorders, such as diabetes.
Some studies suggest CBGa might have anti-cancer properties by inhibiting the proliferation of cancer cells, although more research is needed.
Reason #4: CBG (Cannabigerol)
Treats vasodilation, cancer, neuroprotection, bacterial infections, pain. CBG helps widen blood vessels, which can support better circulation and help with conditions like high blood pressure.
Early research indicates CBG might inhibit the growth of cancer cells, particularly in colon cancer. CBG shows promise in protecting neurons, which could make it useful in treating neurodegenerative conditions like Huntington’s disease or multiple sclerosis.
CBG is also known for its strong antibacterial properties, particularly against resistant bacteria like MRSA.
Reason #5: CBC (Cannabichromene)
Treats pain, inflammation, neurological disorders, and depression. CBC interacts with multiple receptors in the body, contributing to pain relief, anti-inflammatory effects, and improving mood. CBC may promote neurogenesis, or the creation of new brain cells, making it potentially useful for treating neurological disorders.
CBC enhances the overall effectiveness of other cannabinoids, boosting their healing properties through the entourage effect. CBC is also known for its positive impact on acne and other skin conditions due to its anti-inflammatory properties.
When taken in combination, these cannabinoids offer more than just individual symptom relief—they provide holistic wellness by interacting synergistically with the body’s endocannabinoid system.
As more and more of the public get comfortable with the healing powers of the hemp plant, there are still a great many who don’t realize the healing powers of the raw compounds, nor do they realize how the compounds work together to reduce inflammation and enhance overall health. Many even IN the industry don’t understand the healing synergy set up when you combine the raw and cooked compounds. We’re just doing our little bit to get the word out, to help shed some light for folks. It’s not as complicated as, at first, it sounds.
We hope that if you were interested enough to read this article, you might want to participate in ordering our CBD Plus products and letting us know how it helps you.
References for Further Study
Journal of Natural Products (2022): “Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants” – Discusses the role of CBGa and CBDa in preventing COVID-19 infection .
Frontiers in Pharmacology (2020): “Therapeutic Potential of Cannabigerol (CBG): A Wide-Scope of Possible Applications” – Explores the benefits of CBG for treating inflammation, pain, and infection .
British Journal of Pharmacology (2011): “Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects” – Provides insight into the entourage effect and how different cannabinoids and terpenes work together to enhance therapeutic benefits .
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